Gene name:
FTH1 (OK/SW-cl.84;PIG15;FTH;FTHL6) ;
Protein name:
Ferritin heavy chain (Ferritin H subunit) ;
Alternative:
Cell proliferation-inducing gene 15 protein ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited.
Function:
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney.
Subcellular Location:
N/A
Protein Attributes:
50:
MTTASTSQVR | QNYHQDSEAA | INRQINLELY | ASYVYLSMSY | YFDRDDVALK |
100:
NFAKYFLHQS | HEEREHAEKL | MKLQNQRGGR | IFLQDIKKPD | CDDWESGLNA |
150:
MECALHLEKN | VNQSLLELHK | LATDKNDPHL | CDFIETHYLN | EQVKAIKELG |
183:
DHVTNLRKMG | APESGLAEYL | FDKHTLGDSD | NES
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Rabbit
Mouse
Pig
Bovine
Dog
ELISA Kit for Human Ferritin H subunit
ELISA Kit for Human Ferritin H subunit
ELISA Kit for Human Ferritin H subunit
ELISA Kit for Human Ferritin H subunit
ELISA Kit for Human Ferritin H subunit
ELISA Kit for Human Ferritin H subunit
ELISA Kit for Human Ferritin H subunit
CLIA Kit for Human Ferritin H subunit
CLIA Kit for Human Ferritin H subunit
CLIA Kit for Human Ferritin H subunit
CLIA Kit for Human Ferritin H subunit
CLIA Kit for Human Ferritin H subunit
CLIA Kit for Human Ferritin H subunit
CLIA Kit for Human Ferritin H subunit
Polyclonal Antibody for Human Ferritin H subunit
Polyclonal Antibody for Human Ferritin H subunit
Polyclonal Antibody for Human Ferritin H subunit
Polyclonal Antibody for Human Ferritin H subunit
Polyclonal Antibody for Human Ferritin H subunit
Polyclonal Antibody for Human Ferritin H subunit
Polyclonal Antibody for Human Ferritin H subunit
Monoclonal Antibody for Human Ferritin H subunit
Monoclonal Antibody for Human Ferritin H subunit
Monoclonal Antibody for Human Ferritin H subunit
Monoclonal Antibody for Human Ferritin H subunit
Monoclonal Antibody for Human Ferritin H subunit
Monoclonal Antibody for Human Ferritin H subunit
Monoclonal Antibody for Human Ferritin H subunit
Protein for Human Ferritin H subunit
Protein for Human Ferritin H subunit
Protein for Human Ferritin H subunit
Protein for Human Ferritin H subunit
Protein for Human Ferritin H subunit
Protein for Human Ferritin H subunit
Protein for Human Ferritin H subunit
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Hepatocyte .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.
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Proc. Natl. Acad. Sci. U.S.A.83:7226-7230(1986)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Brain .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Brain .
8.
"Detection of ferritin heavy chain by SEREX: a multifunctional molecule in malignant tumour cells."
Franco A.V.
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Gray C.P.
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Myers K.
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Hersey P.
Submitted (1998-08) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
9.
"Identification of a human cell proliferation gene 15."
Kim J.W.
Submitted (2003-03) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
10.
"Identification of immuno-peptidmics that are recognized by tumor-reactive CTL generated from TIL of colon cancer patients."
Shichijo S.
,
Itoh K.
Submitted (2001-05) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Colon adenocarcinoma .
11.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T.
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Suzuki Y.
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Nishikawa T.
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Otsuki T.
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Sugiyama T.
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Wakamatsu A.
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Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Cerebellum .
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
13.
Mural R.J.
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Istrail S.
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Sutton G.G.
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Florea L.
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Eichler E.E.
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Adams M.D.
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Myers E.W.
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Venter J.C.
more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Brain .
tissue :
Cervix .
tissue :
Colon .
tissue :
Lung .
tissue :
Ovary .
tissue :
Prostate .
tissue :
Salivary gland .
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 128-183
16.
"A mutation, in the iron-responsive element of H ferritin mRNA, causing autosomal dominant iron overload."
Kato J.
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Takayama T.
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Ikeda T.
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Niitsu Y.
Am. J. Hum. Genet.69:191-197(2001)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN HFE5;TISSUE SPECIFICITY
17.
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Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-179;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
18.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
19.
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Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-179 AND SER-183;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Liver .
20.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
,
Vermeulen M.
,
Santamaria A.
,
Kumar C.
,
Miller M.L.
,
Jensen L.J.
,
Gnad F.
,
Cox J.
,
Jensen T.S.
,
Nigg E.A.
,
Brunak S.
,
Mann M.
Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-179;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
21.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-179;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
23.
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P.
,
Lasa M.
,
Polevoda B.
,
Gazquez C.
,
Elosegui-Artola A.
,
Kim D.S.
,
De Juan-Pardo E.
,
Demeyer K.
,
Hole K.
,
Larrea E.
,
Timmerman E.
,
Prieto J.
,
Arnesen T.
,
Sherman F.
,
Gevaert K.
,
Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 AND THR-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
24.
"Solving the structure of human H ferritin by genetically engineering intermolecular crystal contacts."
Lawson D.M.
,
Artymiuk P.J.
,
Yewdall S.J.
,
Smith J.M.A.
,
Livingstone J.C.
,
Treffry A.
,
Luzzago A.
,
Levi S.
,
Arosio P.
,
Cesarini G.
,
Thomas C.D.
,
Shaw W.V.
,
Harrison P.M.
Nature349:541-544(1991)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS)
25.
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Cited for : X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS)